Just tracking trended data in general would be sufficient to defeat a LARGE number of common cheats. One of the very few use cases “AI” might actually work for in a positive way. But that puts the burden on the developers and server hosters, and it’s much easier to just burden the players directly instead.
Compatibility is unlikely to be very different. The key is immutability (easy to update, hard to brick your system) and some baked in nice to haves for gaming like some specific drivers/patches and controller support out of the box.