I think it’s left intentionally ambiguous(or might vary depending on the series). They DO leave a lot of signs for Gwen being a supportive figure for transgender people. In Across the Spiderverse, she has a “Protect Trans Kids!” Poster in her room. Her dad has a trans flag patch on his uniform. Her superhero color palette is the trans flag. Pink, light blue, and white is always used when representing her.
Thats not even delving into how her story arc handles those themes/metaphors.
Alternatively you get the funky song that decides to have some weird change up for the last 10-20 seconds which you suffer through on every repeat.
Myne needs no special bloodline! Just near death merging of personalities and Ferdinand accidentally doing the magical equivalent of sex with minors.
The people who would deny genders would totally deny all the crazy extra dimensions.
Weirdly this makes more sense as Tony than the above.
My god that’s an awkward run on