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Cake day: June 29th, 2023

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  • I have this problem with organic chemistry more broadly. On the one hand, I understand that rattling off the IUPAC name of a compound is much less concise and harder to get right than just saying the brand name or chemical name (which, for pharma, is often just as bullshit of a name as the brand name). On the other, you come across names like the Eschenmoser-Claisen rearrangement vs the Johnson-Claisen rearrangement, or the Suzuki vs Stille vs Negishi vs Kumada vs Hiyama/Denmark vs Sonogashira* cross couplings. Each set consists of fundamentally the same reaction with slight variations in the specific reagents. Just saying e.g. “organozinc” instead of “Negishi” would be so much more descriptive. The authors’ names often aren’t even that helpful in an attributive sense. For instance, some of the cross couplings were actually first reported by someone else in that list (though IIRC everyone got at least one), and most of the chemists published work on at least one of the other reactions at some point.

    * Okay fine Sonogashiras are a little different what with the copper co-catalyst, but still, same mech at Pd.


  • Man I just built a new rig last November and went with nvidia specifically to run some niche scientific computing software that only targets CUDA. It took a bit of effort to get it to play nice, but it at least runs pretty well. Unfortunately, now I’m trying to update to KDE6 and play games and boy howdy are there graphics glitches. I really wish HPC academics would ditch CUDA for GPU acceleration, and maybe ifort + mkl while they’re at it.





  • One thing that helped me intuit the “sidereal” result (4) was to consider what happens as the radius of circle B approaches 0. At least in my mind, it seems pretty clear that A has to undergo at least one rotation.

    That said, I am unsure that I would have caught this as a test-taker. Derek’s videos always have some “trick”, putting me on guard, but in a testing scenario I would have seen the answer for 3 with no answer for 4, marked it down, and moved on quickly.