Should do for all - after all, it’s just a matter of prefixes
naa, they do two different things. Sure you can go to the Lutris wine manager under runners and install Lutris versions of wine or select an already installed version of wine. That’s not the same as what ProtonPlus and ProtonUp-qt are doing. They are like Lutris wine manager on steroids, for Lutris and Steam and Bottles and whatever else. Always the possibility I completely overlooked a feature of Lutris.
Well, Steam doesn’t install leading edge versions of Proton. For instance, if you install Battle.net through Steam. Sometimes Battle.net breaks. like here https://www.gamingonlinux.com/2025/01/ge-proton-9-23-released-with-a-battlenet-fix-for-linux-steam-deck/ , so you need the latest changes which wont be available to the Steam Deck, proton-experimental wont get the changes right away. If you just pop open protonup-qt, you can just download ge-proton-9-23. Of course once you have ge-proton-9-23 installed, then the Steam UI can switch between the various versions installed, or you can do it from protonup-qt while you have it open after downloading the latest leading edge proton that you need. I think it’s a good tool, especially for beginners.